ND: |
ME11934964 |
PMID: |
11934964 |
LR: |
20061115 |
CED: |
20020405 |
DCO: |
20020604 |
Autoren: |
Hughes R; Carr A |
Titel: |
A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. |
Quelle: |
Rheumatology (Oxford, England); VOL: 41 (3); p. 279-84 /200203/ |
PM: |
Print |
SU: |
AIM IM |
Sprache: |
English |
CY: |
England |
JID: |
100883501 |
ISSN: |
1462-0324 |
CO: |
RUMAFK |
Institution: |
St Peter's Hospital, Chertsey, Surrey, UK. |
DT: |
Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Schlagwörter |
CT: |
ADULT; ANALGESICS/*administration & dosage; DIETARY SUPPLEMENTS/*; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE/*administration & dosage; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE/*drug therapy; OSTEOARTHRITIS, KNEE/physiopathology; PAIN/*prevention & control; PAIN MEASUREMENT; PLACEBOS; TREATMENT OUTCOME |
CTG: |
ERWACHSENER; ANALGETIKA/*Verabreichung & Dosierung; NAHRUNGSERGÄNZUNGSMITTEL/*; DOPPELBLINDMETHODE; WEIBLICH; GLUCOSAMIN/*Verabreichung & Dosierung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE, KNIE/*Arzneimitteltherapie; OSTEOARTHROSE, KNIE/Pathophysiologie; SCHMERZEN/*Verhütung & Bekämpfung; SCHMERZMESSUNG; PLAZEBOS; BEHANDLUNGSERGEBNIS |
TE: |
Analgesics; Placebos; Glucosamine/3416-24-8 |
CR: |
3416-24-8 |
AB: |
OBJECTIVES: A randomized, placebo-controlled, double-blind trial of the relative effectiveness of glucosamine sulphate and placebo in managing pain in osteoarthritis (OA) of the knee. METHODS: Eighty patients with OA of the knee were recruited from a rheumatology out-patient clinic and received either glucosamine sulphate 1500 mg daily for 6 months or dummy placebo. The primary outcome measure was patients' global assessment of pain in the affected knee. RESULTS: Area under the curve analysis for the primary outcome measure showed no difference between placebo and glucosamine [mean difference 0.15 mm, 95% confidence interval (CI) -8.78 to 9.07]. The placebo response was 33%. There was a statistically significant difference between groups in knee flexion (mean difference 13 degrees, 95% CI -23.13 to -1.97), but this difference was small and could have been due to measurement error. CONCLUSIONS: As a symptom modifier in OA patients with a wide range of pain severities, glucosamine sulphate was no more effective than placebo. |