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Suchschritt : FT=glucosamine AND FT=osteoarthritis
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2/78 von 416    DIMDI: MEDLINE (ME60) © NLM
ND: ME16514823
PMID: 16514823
LR: 20061115
CED: 20060306
DCO: 20060323
Autoren: Svetlova MS; Ignat'ev VK
Titel: Experience with glucosamine hydrochloride in the treatment of patients with osteoarthrosis
Quelle: Terapevticheskii arkhiv; VOL: 77 (12); p. 64-7 /2005/
PM: Print
SU: IM
Sprache: Russian
CY: Russia (Federation)
JID: 2984818R
ISSN: 0040-3660
CO: TEARAI
DT: Comparative Study; English Abstract; Journal Article
Schlagwörter
CT: FEMALE; FOLLOW-UP STUDIES; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS/*drug therapy; OSTEOARTHRITIS/physiopathology; PAIN MEASUREMENT; RANGE OF MOTION, ARTICULAR/drug effects; TREATMENT OUTCOME
CTG: WEIBLICH; VERLAUFSSTUDIEN; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Arzneimitteltherapie; OSTEOARTHROSE/Pathophysiologie; SCHMERZMESSUNG; BEREICH DER GELENKBEWEGLICHKEIT/Arzneimittelwirkungen; BEHANDLUNGSERGEBNIS
TE: Glucosamine/3416-24-8
CR: 3416-24-8
AB: AIM: To study efficacy and tolerance of glucosamine hydrochloride (GH) in osteoarthrosis (OA). MATERIAL AND METHODS: GH was given to patients of the study group (n = 30) for 2 months in a dose 1200 mg/day, while diclofenak was administered to the patients from the control group (n = 24) in a dose 100 mg/day. Clinical, laboratory activity of the disease was estimated before the study, after it, 3 and 6 months later. Side effects were also studied. The efficacy of GH therapy was estimated according to the Lequesne's index, pain intensity on vision-analogy scale (VAS), doses of non-steroidal anti-inflammatory drugs during the day. RESULTS: A decrease in the Lequesne's index and pain by VAS while walking, requirements of NSAIDs in OA patients were revealed. No unfavorable aftereffects of GH were observed. CONCLUSION: GH relieves pain, improves function of the affected joints, reduces necessity in NSAIDs. The effect persists for 3 months. No side effects were registered.
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